When exploring dermatofibroma pathology outlines, it's essential to consider various aspects and implications. Pathology Outlines - Dermatofibroma (cutaneous fibrous histiocytoma). Dermatofibromas (also known as fibrous histiocystomas) are a spectrum of benign dermal-based lesions with fibroblastic and histiocytic differentiation Pathology Outlines - Dermatomyofibroma.
Dermatomyofibroma is a benign tumor of fibroblastic and myofibroblastic differentiation, limited to skin and centered within the dermis Pathology Outlines - Factor XIIIa. Sample pathology report Skin, thigh lesion, biopsy: Dermatofibroma (see comment) Comment: Immunohistochemical studies with FXIIIa demonstrate diffuse positivity within tumor cells, while CD34 is negative. The findings are supportive of the diagnosis of dermatofibroma.
Skin, back mass, excision: Dermatofibrosarcoma protuberans, margins free (see ... Moreover, pathology Outlines - Keloid. Keloid is a benign and potentially disfiguring fibrous tumor caused by increased fibroblast activity in response to skin trauma, causing increased collagen and growth factor production
Furthermore, pathology Outlines - Dermatofibrosarcoma protuberans (DFSP). Sample pathology report Skin, back, biopsy: Dermatofibrosarcoma protuberans (see comment) Comment: Within the dermis and subcutis there is a spindle cell neoplasm with a storiform pattern. From another angle, the cytoplasm is eosinophilic. The nuclei are ovoid and monomorphic with rare mitotic activity. CD34 - 110kDa glycosylated transmembrane protein; it is a marker of vascular endothelial cells and a sensitive but not specific marker for neoangiogenesis
Pathology Outlines - Deep fibrous histiocytoma. Fibrous histiocytoma is a benign fibrohistocytic tumor that arises within the subcutaneous or deep soft tissues and rarely metastasizes Pathology Outlines - Desmoplastic melanoma.
Skin melanocytic tumor - Desmoplastic melanoma Rare desmoplastic / fibrosing variant of spindle cell melanoma with > 90% stroma / collagen Answer A is incorrect because while dermatofibroma can be similar in appearance, it is typically more cellular and is most common on the legs. Answer B is incorrect because while hypertrophic scars can overlap in histological appearance with keloid, they are generally more cellular and have less keloidal collagen. This perspective suggests that, pathology Outlines - D2-40 (Podoplanin).
Stains & molecular markers - Podoplanin is a 40 kDa, transmembrane, oncofetal, O linked sialoglycoprotein (mucin type) found on lymphatic endothelium, mesothelium and fetal testis; D2-40 is a monoclonal antibody that reacts to podoplanin
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